These investigations, however, have yet to be extended to cats since these pets share similar environments and living conditions with their human owners as well. It has been recognized that domestic dogs fulfill these criteria. Ideally, testing should occur in species that are evolutionarily close to humans, similar in size, have high genetic diversity, and share the same environment as humans. Interventions to slow aging are being sought. Age is undoubtedly the biggest risk factor for a vast majority of diseases in animals, and cats are no exception. The maximum (confirmed) lifespan of cats is 30 years according to the animal age data base (anAge) but most cats succumb to diseases before they are 20 years old. Most owners of domestic cats lament the short lifespan of these widely popular pets. It is expected that these epigenetic clocks for cats possess the potential to be further developed for monitoring feline health as well as being used for identifying and validating anti-aging interventions. We demonstrate that these domestic cat clocks also lead to high age correlations in cheetahs, tigers, and lions. From these, we present 3 epigenetic clocks for cats of which, one applies only to blood samples from cats, while the remaining two dual-species human-cat clocks apply both to cats and humans. Methylation levels of these CpGs are measured using a custom-designed Infinium array (HorvathMammalMethylChip40). Here, we describe epigenetic clocks for the domestic cat ( Felis catus), based on methylation profiles of CpGs with flanking DNA sequences that are highly conserved between multiple mammalian species. This is exemplified by recent development of epigenetic clocks for mice and other mammalian species. Although these human epigenetic clocks are not immediately applicable to all species of the animal kingdom, the principles underpinning them appear to be conserved even in animals that are evolutionarily far removed from humans. A free gift of a similar value may be substituted if stock of the current free gift is exhausted.Human DNA methylation profiles have been used successfully to develop highly accurate biomarkers of aging (“epigenetic clocks”). Products are dispatched from Innovations, 431 Warringah Road, Frenchs Forest, NSW, Australia.ġ1. All products are supplied for domestic use only and not for any commercial use.ġ0. You will receive an immediate credit or refund for the full purchase price (excluding delivery and insurance).ĩ. All batteries must be removed from electrical devices before returning the product. Products returned must be in original condition and packaging. Personalised items cannot be returned unless faulty.Ĩ. Occasionally, prototype samples are photographed. But please note, we cannot deliver to the following postcodes - 28.Ħ. We deliver throughout mainland Australia and Tasmania. If you are using our interest FREE payment terms, delivery and insurance will be charged in your first instalment.ĥ. Please allow four to six weeks for despatch from order date of hampers and products that can be personalised (whether they are personalised or not) due to the complex systems involved.Ĥ. For couriered items, dispatch and delivery times may vary, please contact us for further information. Due to stock availability of some products, please allow 21 days for their delivery. We dispatch weekdays and delivery times will vary depending on your distance from our dispatch point in Sydney. On average we will dispatch in stock orders within 2 business days of the order being placed. We strive to deliver every order as soon as possible. All of our quality products come with a 12 Month money back guarantee if you are not completely satisfied.ģ. The items bought are delivered to your door by Australia Post or courier. Charges are per order and are not based on weight.Ģ. The delivery and insurance cost is for delivery within Australia.
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